DL-4-FluoroglutaMic acid

Names

[ Name ]:
DL-4-FluoroglutaMic acid

[Synonym ]:
4-Fluoro-2-aminopentanedioic acid
2-Amino-4-fluoropentane-1,5-dioic acid
EINECS 220-302-8
4-Fluoro-Glutamic Acid
threo-4-fluoroglutamic acid
D,L-erythro,threo-4-fluoroglutamic acid
H-4-F-DL-Glu-OH
erythro-4-fluoroglutamic acid
DL-erythro-4-fluoroglutamic acid
DL-4-FLUOROGLUTAMIC ACID
MFCD00055778

Biological Activity

[Description]:

4-Fluoro-DL-glutamic acid is a glutamic acid derivative[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].

[References]

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

Chemical & Physical Properties

[ Density]:
1.498 g/cm3

[ Boiling Point ]:
342.4ºC at 760 mmHg

[ Melting Point ]:
185°C (dec.)

[ Molecular Formula ]:
C₅H₈FNO₄

[ Molecular Weight ]:
165.12000

[ Flash Point ]:
160.9ºC

[ Exact Mass ]:
165.04400

[ PSA ]:
100.62000

[ Vapour Pressure ]:
1.37E-05mmHg at 25°C

[ Index of Refraction ]:
1.491

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

4-[18F]fluoroglutamic acid (BAY 85-8050), a new amino acid radiotracer for PET imaging of tumors: synthesis and in vitro characterization.

J. Med. Chem. 54(1) , 406-10, (2011)

There is a high demand for tumor specific PET tracers in oncology imaging. Besides glucose, certain amino acids also serve as energy sources and anabolic precursors for tumors. Therefore, (18)F-labele...

Mutations of the Corynebacterium glutamicum NCgl1221 gene, encoding a mechanosensitive channel homolog, induce L-glutamic acid production.

Appl. Environ. Microbiol. 73(14) , 4491-8, (2007)

Corynebacterium glutamicum is a biotin auxotroph that secretes L-glutamic acid in response to biotin limitation; this process is employed in industrial L-glutamic acid production. Fatty acid ester sur...

Vitamin K-dependent carboxylation. Study of the hydrogen abstraction stereochemistry with gamma-fluoroglutamic acid-containing peptides.

J. Biol. Chem. 258(13) , 7897-9, (1983)

Two pentapeptides Phe-Leu-X-Glu-Val where X is either the L-threo-gamma-fluoroglutamic acid or the L-erythro-isomer have been synthesized and tested as substrates in the vitamin K-dependent carboxylat...

Related Compounds

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