8RK59

Names

[ Name ]:
8RK59

Biological Activity

[Description]:

8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

[Target]

UCHL1 (ubiquitin C-terminal hydrolase L1)[1]

[In Vitro]

8RK59 (5 μM, 24 h) 仅与野生型 UCHL1 结合，但不与催化失活的 UCHL1 结合，表明探针结合位点是活性位点半胱氨酸[1]。

[References]

[1]. Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₃₉BF₂N₁₀O₂S

[ Molecular Weight ]:
688.60

Related Compounds

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