<Suppliers Price>

Trk-IN-11

Names

[ CAS No. ]:
2700265-62-7

[ Name ]:
Trk-IN-11

Biological Activity

[Description]:

Trk-IN-11 (Compound 14h) is a potent inhibitor of TRK (IC50 = 1.4, 1.8 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-11 has the potential for the research of cancer disease[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Trk Receptor

[References]

[1]. Fan Y, et al. Pyrizolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: Design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2022;63:128646.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H22FN5O3

[ Molecular Weight ]:
411.43

Related Compounds