Topoisomerase II inhibitor 7

Names

[ CAS No. ]:
2697171-03-0

[ Name ]:
Topoisomerase II inhibitor 7

Biological Activity

[Description]:

Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC50 of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[Target]

topoisomerase II alpha:3.19 μM (IC50)


[References]

[1]. Nemr MTM, et, al. Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity. Bioorg Chem. 2020 Dec;105:104446.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H28BrN5O5S

[ Molecular Weight ]:
674.56

Related Compounds

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