<Suppliers Price>

N-Ethyl-2-pyrrolidone

Names

[ CAS No. ]:
2687-91-4

[ Name ]:
N-Ethyl-2-pyrrolidone

[Synonym ]:
N-Ethyl-2-Pyrrolidone
1-Ethyl-2-pyrrolidone
Agsol Ex 2
1-Ethyl-2-pyrrolidinone
N-Ethylpyrrolidone
N-Efhyl-2-Pyrrolidone
N-ethyl-2-pyrrolidinone
N-Ethyl-2-pyrrolidon
N-ethylpyrrolidinone
2-Pyrrolidinone, 1-ethyl-
ethyl-2-pyrrolidone
N-Ethyl-a-pyrrolidone
1-ethylpyrrolidin-2-one
N-Ethyl-2-azapentanone
NEP
EINECS 220-250-6
ethyl-pyrrolidinone
MFCD00003199
N-Ethyl-Pyrrolidone

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
203.6±0.0 °C at 760 mmHg

[ Melting Point ]:
< -120 °C

[ Molecular Formula ]:
C6H11NO

[ Molecular Weight ]:
113.158

[ Flash Point ]:
76.1±0.0 °C

[ Exact Mass ]:
113.084061

[ PSA ]:
20.31000

[ LogP ]:
0.13

[ Vapour Pressure ]:
0.3±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.465

[ Storage condition ]:
-70°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY5769250
CHEMICAL NAME :
2-Pyrrolidinone, 1-ethyl-
CAS REGISTRY NUMBER :
2687-91-4
BEILSTEIN REFERENCE NO. :
0107971
LAST UPDATED :
199806
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H11-N-O
MOLECULAR WEIGHT :
113.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1350 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Liver - other changes Kidney, Ureter, Bladder - other changes
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 26,475,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359

Safety Information

[ Symbol ]:

GHS05, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318-H360D

[ Precautionary Statements ]:
P201-P280-P305 + P351 + P338 + P310-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
1

[ RTECS ]:
UY5769250

[ HS Code ]:
2933790090

Synthetic Route

Precursor & DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.

Dis. Model Mech. 7(12) , 1385-95, (2014)

The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic str...

Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells.

Toxicol. Sci. 145 , 128-37, (2015)

Levels of amyloid beta (Aβ) in the central nervous system are regulated by the balance between its synthesis and degradation. Neprilysin (NEP) is associated with Alzheimer's disease (AD) by its abilit...

Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.

Molecular Neurodegeneration 10 , 56, (2015)

Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer's disease (AD) pathogenesis. Previous studies suggested that statins promote IDE...


More Articles


Related Compounds