Antioxidant agent-5

Names

[ CAS No. ]:
2684291-60-7

[ Name ]:
Antioxidant agent-5

Biological Activity

[Description]:

Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Cardiovascular Disease

[References]

[1]. Xie HX, et al. Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway. Bioorg Chem. 2022 Mar;120:105606.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24N6O

[ Molecular Weight ]:
412.49

Related Compounds