2684291-60-7

2684291-60-7 structure

Name: Antioxidant agent-5
Chemical Name: Antioxidant agent-5
CAS Number: 2684291-60-7
Molecular Formula: C₂₄H₂₄N₆O
Molecular Weight: 412.49
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-08-20 18:16:36
Modify Date: 2024-01-06 16:56:24
Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1].

Name	Antioxidant agent-5

Description	Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Cardiovascular Disease
References	[1]. Xie HX, et al. Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway. Bioorg Chem. 2022 Mar;120:105606.

Molecular Formula	C₂₄H₂₄N₆O
Molecular Weight	412.49