BET BD2-IN-1

Names

[ CAS No. ]:
2677039-24-4

[ Name ]:
BET BD2-IN-1

Biological Activity

[Description]:

BET BD2-IN-1 (compound 45) is a potent and selective inhibitor of BET BD2 (IC50=1.6 nM). BET BD2-IN-1 inhibits the differentiation of Th17 cells by decreasing the activation of STAT3 and NF-κB. BET BD2-IN-1 is used in psoriasis and inflammatory bowel disease (IBD) research[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

BRD2 BD1:570 nM (IC50)

BRD2 BD2:5.9 nM (IC50)

BRD3 BD1:465 nM (IC50)

BRD3 BD2:6.0 mM (IC50)

BRD4 BD1:524 nM (IC50)

BRD4 BD2:1.6 nM (IC50)

BRDT BD1:527 nM (IC50)

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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