D-erythro-Sphingosine hydrochloride
Names
Biological Activity
[Description]:
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation[1][2].
[Related Catalog]:
[Target]
TRPM3
Retinoblastoma protein
[In Vitro]
Extracellular application of D-erythro-Sphingosine (20 μM) induces an increase in [Ca2+]i in TRPM3-transfected HEK293 cells within 20 to 30 s after start of application, whereas nontransfected control cells (NT) shows only very small responses[1]. D-erythro-Sphingosine (10 μM) induces currents through TRPM3[1]. Induction of retinoblastoma protein dephosphorylation by D-erythro-Sphingosine (500 nM; 24 h) precede inhibition of growth and a specific arrest in the G0/G1 phase of the cell cycle[2].
Chemical & Physical Properties
[ Molecular Formula ]:
C18H38ClNO2
[ Molecular Weight ]:
335.95300
[ Exact Mass ]:
335.25900
[ PSA ]:
66.48000
[ LogP ]:
5.42650