FGFR-IN-11

Names

[ CAS No. ]:
2658488-68-5

[ Name ]:
FGFR-IN-11

Biological Activity

[Description]:

FGFR-IN-11 (compound I-5) is an orally active and covalent FGFR inhibitor with IC50 values of 9.9 nM (FGFR1), 3.1 nM (FGFR2), 16 nM (FGFR3), and 1.8 nM (FGFR4), respectively. FGFR-IN-11 inhibits multiple cancer cell proliferation with nanomolar activity. FGFR-IN-11 inhibits tumor growth significantly in xenograft mice models[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR

[Target]

FGFR1:9.9 nM (IC50)

FGFR2:3.1 nM (IC50)

FGFR3:16 nM (IC50)

FGFR4:1.8 nM (IC50)


[References]

[1]. Hu S, et al. Discovery and Structural Optimization of Novel Quinolone Derivatives as Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. J Med Chem. 2023 Jul 13;66(13):8858-8875.  

Chemical & Physical Properties

[ Molecular Formula ]:
C28H29ClN4O4

[ Molecular Weight ]:
521.01

Related Compounds

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