hiCE inhibitor-1

Names

[ Name ]:
hiCE inhibitor-1

Biological Activity

[Description]:

hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[References]

[1]. Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₄Cl₂N₂O₄S₂

[ Molecular Weight ]:
457.35

Related Compounds

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