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2654-68-4

2654-68-4 structure

2654-68-4 structure

Name: hiCE inhibitor-1
Chemical Name: hiCE inhibitor-1
CAS Number: 2654-68-4
Molecular Formula: C₁₈H₁₄Cl₂N₂O₄S₂
Molecular Weight: 457.35
Catalog: Research Areas Metabolic Disease
Create Date: 2022-11-21 16:35:23
Modify Date: 2025-10-12 08:53:35
hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].

Name	hiCE inhibitor-1

Description	hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43.

Molecular Formula	C₁₈H₁₄Cl₂N₂O₄S₂
Molecular Weight	457.35

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