TLR7/8 agonist 9

Names

[ CAS No. ]:
2649170-17-0

[ Name ]:
TLR7/8 agonist 9

Biological Activity

[Description]:

TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Cancer

[Target]

EC50s: 40 nM and 23 nM for hTLR7/8[1]


[References]

[1]. Wang Z, et al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H26N6O

[ Molecular Weight ]:
366.46

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.