2649170-17-0

2649170-17-0 structure

Name: TLR7/8 agonist 9
Chemical Name: TLR7/8 agonist 9
CAS Number: 2649170-17-0
Molecular Formula: C₂₀H₂₆N₆O
Molecular Weight: 366.46
Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
Create Date: 2023-10-22 20:52:00
Modify Date: 2025-08-25 12:24:53
TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy[1].

Name	TLR7/8 agonist 9

Description	TLR7/8 agonist 9 (Compound 25a) is a TLR7/8 agonist, with EC50s of 40 nM and 23 nM for hTLR7/8. TLR7/8 agonist 9 has anti-tumor activity and improves the antitumor activity of PD-1/PD-L1 blockade. TLR7/8 agonist 9 can be used for research of cancer immunotherapy[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Cancer
Target	EC50s: 40 nM and 23 nM for hTLR7/8[1]
References	[1]. Wang Z, et al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64(11):7507-7532.

Molecular Formula	C₂₀H₂₆N₆O
Molecular Weight	366.46