CQ211

Names

[ Name ]:
CQ211

Biological Activity

[Description]:

CQ211 is a potent and selective RIOK2 inhibitor with a Kd of 6.1 nM. CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Kd: 6.1 nM (RIOK2)[1]

[In Vivo]

CQ211 (25 mg/kg) inhibits the tumor progression with tumor growth inhibition (TGI) of 30.9% in rats[1].

[References]

[1]. Ouyang Y, et al. Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J Med Chem. 2022 Jun 9;65(11):7833-7842.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₂F₃N₇O₂

[ Molecular Weight ]:
521.49

Related Compounds

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