DGKα-IN-2

Names

[ Name ]:
DGKα-IN-2

Biological Activity

[Description]:

DGKα-IN-2 (example 48) is a DGKα inhibitor with the IC50 of 0.9 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

0.9 nM (DGKα)

[References]

[1]. Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₂F₃N₃O₄

[ Molecular Weight ]:
461.43

Related Compounds

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