DGKα-IN-3

Names

[ Name ]:
DGKα-IN-3

Biological Activity

[Description]:

DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[Target]

283 nM (DGKα)

[References]

[1]. Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₇F₃N₄O₃

[ Molecular Weight ]:
500.51

Related Compounds

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