HIF-2α-IN-9

Names

[ Name ]:
HIF-2α-IN-9

Biological Activity

[Description]:

HIF-2α-IN-9 (compound 35r) is an inhibitor ofHIF-2α. HIF-2α-IN-9 inhibits VEGF-A (IC50=305 nM), and regulates growth-promoting genes in tumor cells, reactivates macrophage-mediated tumor immunity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[Target]

HIF-2α[1]

[References]

[1]. Buchstaller H P, et al. Discovery of Cycloalkyl [c] thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2伪 Inhibitors[J]. Journal of Medicinal Chemistry, 2023..

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₃F₅O₄S₂

[ Molecular Weight ]:
380.35

Related Compounds

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