FD274

Names

[ CAS No. ]:
2641899-38-7

[ Name ]:
FD274

Biological Activity

[Description]:

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research[1].

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR
Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα:0.65 nM (IC50)

PI3Kβ:1.57 nM (IC50)

PI3Kδ:0.65 nM (IC50)

PI3Kγ:0.42 nM (IC50)

mTOR:2.03 nM (IC50)


[References]

[1]. Chengbin Yang, et al. Discovery of N-(2-chloro-5-(3-(pyridin-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (FD274) as a highly potent PI3K/mTOR dual inhibitor for the treatment of acute myeloid leukemia. Eur J Med Chem. 2023 Oct 5;258:115543.  

Chemical & Physical Properties

[ Molecular Formula ]:
C22H14ClFN6O2S

[ Molecular Weight ]:
480.90

Related Compounds