PPT

Names

[ Name ]:
PPT

[Synonym ]:
Phenol, 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-
1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole
4,4',4''-(4-Propyl-1H-pyrazole-1,3,5-triyl)triphenol
4-[2,3-bis(4-hydroxyphenyl)-4-propyl-1H-pyrazol-5-ylidene]cyclohexa-2,5-dien-1-one
4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol
Propyl pyrazole triol

Biological Activity

[Description]:

Propyl pyrazole triol (PPT) is an estrogen receptor alpha (ERσ) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Research Areas >> Cancer

[Target]

Estrogen receptor alpha[1]

[In Vitro]

The EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM in ERα-U2OS-Luc cells[1].

[References]

[1]. https://www.ncbi.nlm.nih.gov/pubmed/18644836/

[2]. Stauffer SR, et al. Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem. 2000 Dec 28;43(26):4934-47.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
630.0±55.0 °C at 760 mmHg

[ Melting Point ]:
230 ºC (decomp)

[ Molecular Formula ]:
C₂₄H₂₂N₂O₃

[ Molecular Weight ]:
386.44

[ Flash Point ]:
334.8±31.5 °C

[ Exact Mass ]:
386.163055

[ PSA ]:
78.51000

[ LogP ]:
5.95

[ Appearance of Characters ]:
solid,off-white

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.642

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Practically insoluble (0.016 g/L) (25 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice.

Environ. Health Perspect. 123(4) , 344-52, (2015)

Concerns regarding potential endocrine-disrupting chemicals (EDCs) have led to a need for methods to evaluate candidate estrogenic chemicals. Our previous evaluations of two such EDCs revealed a respo...

Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomas.

Anticancer Drugs 26(3) , 293-300, (2015)

Tamoxifen, a selective estrogen receptor modulator, is widely used in the chemotherapy of estrogen receptor-positive breast cancer. Recent studies have indicated that tamoxifen might have a potential ...

Estradiol and Estrogen Receptor Agonists Oppose Oncogenic Actions of Leptin in HepG2 Cells.

PLoS ONE 11 , e0151455, (2016)

Obesity is a significant risk factor for certain cancers, including hepatocellular carcinoma (HCC). Leptin, a hormone secreted by white adipose tissue, precipitates HCC development. Epidemiology data ...

Related Compounds

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