EGFR-IN-22

Names

[ Name ]:
EGFR-IN-22

Biological Activity

[Description]:

EGFR-IN-22 is a potent EGFR inhibitor with IC50s of 4.91 nM and 0.54 nM for wild type EGFR and EGFRL858R/T790M/C797S, respectively (CN112538072A, compound 243)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFRL858R/T790M/C797S:0.54 nM (IC50)

EGFR (WT):4.91 nM (IC50)

[References]

[1]. EGFR-IN-22 is a potent EGFR inhibitor with IC50 of 4.91 nM and 0.54 nM for wild type EGFR and EGFR^{L858R/T790M/C797S}, respectively (CN112538072A, compound 243)^[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₈H₄₇BrFN₁₀O₂P

[ Molecular Weight ]:
805.72

EGFR-IN-22

Names

Biological Activity

Chemical & Physical Properties

Related Compounds