Benzisothiazolone

Names

[ Name ]:
Benzisothiazolone

[Synonym ]:
Benzisothiazolone
2,3-dihydro-3-oxo-1,2-benzisothiazole
benzo[d]isothiazol-3-one
Proxan
proxel
Proxel AB
proxil
1,2-Benzothiazol-3-ol
EINECS 220-120-9
Benzisothiazolone (BIT)
1,2-benzoisothiazolin-3-one
BIOCIDE--BIT
Proxel XL
MFCD00127753
T56 BSMVJ
Benzocil
1,2-benzisothiazol-3-one
1,2-Benzisothiazol-3(2H)-one
T56 BSNJ DQ
BIT
proxelpl
1,2-Benzisothiazolin-3-One
1,2-Benzothiazol-3(2H)-one
PROXELHL
1,2-Benzisothiazol-3-ol

Biological Activity

[Description]:

Benzisothiazolone is an isothiazolone fungicide. Benzisothiazolone has growth inhibiting activity against E. coli ATCC 8739 and saccharornyces pombe NCYC 1354. Benzisothiazolone can be used in the study of growth inhibition model [1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Others >> Others

[References]

[1]. CollierPJ, et al. Growth inhibitory and biocidal activity of some isothiazolonebiocides. J Appl Bacteriol. 1990 Oct;69(4):569-77.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
204.5±23.0 °C at 760 mmHg

[ Melting Point ]:
154-158ºC

[ Molecular Formula ]:
C₇H₅NOS

[ Molecular Weight ]:
151.19

[ Flash Point ]:
77.5±22.6 °C

[ Exact Mass ]:
151.009186

[ PSA ]:
61.10000

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.745

[ Water Solubility ]:
Soluble in dichloromethane, dimethyl sulfoxide, methanol.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4620000

CHEMICAL NAME :: 1,2-Benzisothiazol-3(2H)-one

CAS REGISTRY NUMBER :: 2634-33-5

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H5-N-O-S

MOLECULAR WEIGHT :: 151.19

WISWESSER LINE NOTATION :: T56 BSMVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 3,385,1971 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9375 No. of Facilities: 4586 (estimated) No. of Industries: 57 No. of Occupations: 57 No. of Employees: 92923 (estimated) No. of Female Employees: 15307 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H317-H318-H400

[ Precautionary Statements ]:
P273-P280-P301 + P312 + P330-P305 + P351 + P338 + P310-P333 + P313-P391

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R38;R41;R43;R50

[ Safety Phrases ]:
S24-S26-S37/39-S61

[ RIDADR ]:
UN 3077

[ WGK Germany ]:
2

[ RTECS ]:
DE4620000

[ Packaging Group ]:
III

[ HS Code ]:
2934200090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Preparation

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Benzisothiazolinone as a useful template for the design of new monoacylglycerol lipase inhibitors: investigation of the target residues and comparison with octhilinone.

Bioorg. Med. Chem. Lett. 21(24) , 7321-4, (2011)

The regulation of 2-arachidonoylglycerol (2-AG) levels is a major issue as 2-AG has been proven to participate in numerous physiopathological phenomena such as neuroprotection or analgesia. Octhilinon...

Solid-phase synthesis of benzisothiazolones as serine protease inhibitors.

Bioorg. Med. Chem. Lett. 9(5) , 663-6, (1999)

An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been...

A colorimetric assay for high-throughput screening of inhibitors of herpes simplex virus type 1 alkaline nuclease.

Anal. Biochem. 293(2) , 239-45, (2001)

Herpes simplex virus type 1 (HSV-1) encodes a deoxyribonuclease that is frequently referred to as alkaline nuclease (AN) because of its elevated pH optimum. Studies with recombinant viruses which cont...