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PBIT

Names

[ CAS No. ]:
2514-30-9

[ Name ]:
PBIT

[Synonym ]:
2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
2-(p-tolyl)benzo[d]isothiazol-3(2H)-one
2-p-Tolyl-benz[d]isothiazol-3-on
2-(4-Methylphenyl)-1,2-benzothiazol-3(2H)-one
2-p-tolyl-benz[d]isothiazol-3-one
2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one 2-p-Tolyl-1,2-benzisothiazolin-3-one
2-(p-methylphenyl)-1,2-benzisothiazolin-3-one
2-(4-methylphenyl)benzo[d]isothiazol-3(2H)-one
2-p-tolyl-benzo[d]isothiazol-3-one
HMS1493C06
1,2-Benzisothiazol-3(2H)-one, 2-(4-methylphenyl)-
HMS2576N21
PBIT

Biological Activity

[Description]:

PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1(JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1 ) histone demethylase an IC50 of about 3 μM . PBIT also inhibits JARID1A and JARID1C with IC5 s of 6 and 4.9 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Demethylase

[References]

[1]. Sayegh J, et al. Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen. J Biol Chem. 2013 Mar 29;288(13):9408-17.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
418.2±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H11NOS

[ Molecular Weight ]:
241.31

[ Flash Point ]:
206.7±26.8 °C

[ Exact Mass ]:
241.056137

[ PSA ]:
50.24000

[ LogP ]:
3.73

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.680

MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Precursor & DownStream


Related Compounds

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