SMD-3040 intermediate-2

Names

[ CAS No. ]:
2632308-00-8

[ Name ]:
SMD-3040 intermediate-2

Biological Activity

[Description]:

SMD-3040 intermediate-2 is an intermediate in the synthesis of SMD-3040 (HY-156568). SMD-3040 contains SMARCA2/4 ligands, linker and VHL ligands and is a selective SMARCA2 degrader. MD-3040 can be used for ADC drug synthesis and has strong tumor growth inhibition in tumor xenograft models[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Yang L, et.al. Discovery of SMD-3040 as a Potent and Selective SMARCA2 PROTAC Degrader with Strong in vivo Antitumor Activity. J Med Chem. 2023 Jul 31.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H28ClN3O2

[ Molecular Weight ]:
389.92

Related Compounds

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