ARD-1676

Names

[ Name ]:
ARD-1676

Biological Activity

[Description]:

ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC

Signaling Pathways >> Others >> Androgen Receptor

[References]

[1]. Xiang W, et al. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. J Med Chem. 2023 Sep 8..

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₄H₄₆ClN₇O₅

[ Molecular Weight ]:
788.33

Related Compounds

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