2632305-36-1

2632305-36-1 structure

Name: ARD-1676
Chemical Name: ARD-1676
CAS Number: 2632305-36-1
Molecular Formula: C₄₄H₄₆ClN₇O₅
Molecular Weight: 788.33
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2024-04-09 17:46:10
Modify Date: 2024-04-09 17:46:10
ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].

Name	ARD-1676

Description	ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Xiang W, et al. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. J Med Chem. 2023 Sep 8..

Molecular Formula	C₄₄H₄₆ClN₇O₅
Molecular Weight	788.33