ASPER-29

Names

[ Name ]:
ASPER-29

Biological Activity

[Description]:

ASPER-29 is Asperphenamate HY-129578 analog. ASPER-29 also is a dual cathepsin L and S inhibitor with IC50 value of 6.03 μM and 5.02 μM, respectively. ASPER-29 can be used for the research of the migration and invasion of cancer[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[Target]

cathepsin L:6.03 μM (IC50)

cathepsin S:5.02 μM (IC50)

[In Vitro]

ASPER-29 具有双重 Cat L 和 S 抑制效力，IC50 值分别为 6.03 μM 和 5.02 μM[1]。 ASPER-29 对胰腺癌 BxPC-3 和 PANC-1 细胞显示出明确的抗转移作用[1]。

[References]

[1]. Haoqiang Huang, et al. Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells. Bioorg Med Chem Lett. 2022 Nov 23;80:129087.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₁H₂₉BrN₂O₅S

[ Molecular Weight ]:
621.54

Related Compounds

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