Sorbitan, tri-(9Z)-9-octadecenoate

Names

[ Name ]:
Sorbitan, tri-(9Z)-9-octadecenoate

[Synonym ]:
1,4-anhydro-2,3,6-tri-O--(9Z)-octadec-9-enoyl-D-glucitol
emsorb2503
te33
SPAN NO 85
EINECS 247-569-3
Sorbitane trioleate
Sorbitan, tri-(9Z)-9-octadecenoate
1,4-anhydro-2,3,6-tri-O--(9Z)-octadec-9-enoyl-L-iditol
ionets85
SPAN 85
(Sorbitan Trioleate)
L-iditol, 1,4-anhydro-2,3,6-tris-O-[(9Z)-1-oxo-9-octadecenyl]-
SPAN(R) 85
L-Iditol, 1,4-anhydro-2,3,6-tris-O-[(9Z)-1-oxo-9-octadecen-1-yl]-
MFCD00133820
op85r
glycomulto
crill5
1,4-Anhydro-2,3,6-tri-O--(9Z)-9-octadecenoyl-L-iditol
emasol430

Biological Activity

[Description]:

Sorbitan trioleate is an orally active nonionic surfactant with low toxicity (LD≥200 mg/kg). Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. YAMAMOTO H, et al. Study on subacute toxicity of intravenous sorbitan trioleate (STO) in Wistar rats[J]. The Journal of Toxicological Sciences, 1983, 8(4): 301-310.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
887.4±65.0 °C at 760 mmHg

[ Melting Point ]:
-14 °C

[ Molecular Formula ]:
C₆₀H₁₀₈O₈

[ Molecular Weight ]:
957.495

[ Flash Point ]:
223.7±27.8 °C

[ Exact Mass ]:
956.804443

[ PSA ]:
108.36000

[ LogP ]:
24.10

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.499

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WG2934550

CHEMICAL NAME :: Sorbitan, tris(9-octadecenoate), (Z)-

CAS REGISTRY NUMBER :: 26266-58-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C60-H108-O8

MOLECULAR WEIGHT :: 957.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg/35D-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Blood - changes in spleen Blood - changes in erythrocyte (RBC) count

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8,301,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82920 No. of Facilities: 416 (estimated) No. of Industries: 16 No. of Occupations: 25 No. of Employees: 19949 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82920 No. of Facilities: 1632 (estimated) No. of Industries: 17 No. of Occupations: 21 No. of Employees: 25056 (estimated) No. of Female Employees: 5808 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
WG2934550

[ HS Code ]:
2932190090

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Fatty alcohols or fatty acids as niosomal hybrid carrier: effect on vesicle size, encapsulation efficiency and in vitro dye release.

Colloids Surf. B Biointerfaces 58(1) , 68-71, (2007)

Niosomal hybrid mixtures are prepared with bilayer stabilizer cholesterol from non-ionic surfactants span 20 (HLB value 8.6), span 60 (HLB 4.7) and span 85 (HLB 1.8) in presence of dicetyl phosphate (...

A microcalorimetric investigation of the interaction of surfactants with crystalline and partially crystalline salbutamol sulphate in a model inhalation aerosol system.

Pharm. Res. 12(11) , 1689-93, (1995)

The purpose of the work is to study the adsorption of Oleic acid and Span 85 (materials frequently used in aerosols as surfactants) onto partially amorphous and essentially crystalline salbutamol sulp...

Effects of different nonionic surfactants on in vitro fermentation characteristics of cereal straws.

J. Anim. Sci. 87(3) , 1085-96, (2009)

The effects of 3 nonionic surfactants (NIS), including alkyl polyglucoside (APG), sorbitan trioleate (Span85), and polyoxyethylene sorbitan monostearate (Tween80), on in vitro fermentation characteris...