SC 22716

Names

[ Name ]:
SC 22716

[Synonym ]:
1-[2-(biphenyloxy)ethyl]pyrrolidine
1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine

Biological Activity

[Description]:

SC-22716 is a potent, competitive, reversible inhibitor of human LTA4 hydrolase, with an IC50 of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Aminopeptidase

Research Areas >> Inflammation/Immunology

[References]

[1]. Penning TD, et, al. Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase. J Med Chem. 2000 Feb 24;43(4):721-35.

Chemical & Physical Properties

[ Density]:
1.065g/cm3

[ Boiling Point ]:
418.5ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₁NO

[ Molecular Weight ]:
267.36500

[ Flash Point ]:
122.8ºC

[ Exact Mass ]:
267.16200

[ PSA ]:
12.47000

[ LogP ]:
3.76610

[ Vapour Pressure ]:
3.27E-07mmHg at 25°C

[ Index of Refraction ]:
1.568

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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