(Rac)-Etavopivat

Names

[ CAS No. ]:
2622070-93-1

[ Name ]:
(Rac)-Etavopivat

Biological Activity

[Description]:

(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[In Vitro]

Etavopivat (20 μM, 4 h)可以改善人红细胞中血红蛋白-氧亲和力并降低了镰状点 (PoS)[1]。

[In Vivo]

Etavopivat（口服，3-22mg/kg，每天一次，5天）在 8 mg/kg和 22 mg/kg 的剂量下引起食蟹猴 2,3-DPG 和 ATP 的增加[1]。

[References]

[1]. Patricia Schroeder, et al. Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease. J Pharmacol Exp Ther. 2022 Mar;380(3):210-219.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₃N₃O₆S

[ Molecular Weight ]:
457.50

(Rac)-Etavopivat

Names

Biological Activity

Chemical & Physical Properties

Related Compounds