(S)-PERK-IN-5

Names

[ CAS No. ]:
2616821-92-0

[ Name ]:
(S)-PERK-IN-5

Biological Activity

[Description]:

(S)-PERK-IN-5 is the S-enantiomer of PERK-IN-5. (S)-PERK-IN-5 (example 39) is a PERK inhibitor, with an IC50 of 0.101-0.250 μM[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> PERK

[References]

[1]. Calvo V, et al. Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors. Bioorg Med Chem Lett. 2021;43:128058.

[2]. Alan C. Rigby, et al. Perk inhibitors for treating viral infections. WO2021231782A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₆F₂N₄O₃

[ Molecular Weight ]:
468.50

Related Compounds