N-Acetyl-D-cysteine

Names

[ Name ]:
N-Acetyl-D-cysteine

[Synonym ]:
acetylcysteine
Lopac-A-7250
D-Cysteine, N-acetyl-
N-Acetylcysteine
N-acetyl-3-mercaptoalanine
(2S)-2-acetylamino-3-sulfanylpropanoic acid
N-Acetyl-D-cysteine
D-Cysteine,N-acetyl

Biological Activity

[Description]:

N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway[1].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

N-Acetyl-D-cysteine (20 mM; 1 hour pretreatment; 12 hours) does not increase intracellular GSH levels, but GSH monoester does. D-NAC can not enhance hypoxic apoptosis. This demonstrate that GSH rather than D-NAC or NAC is responsible for enhancing hypoxic apoptosis[3].

[References]

[1]. Maika Deffieu, et al. Glutathione Participates in the Regulation of Mitophagy in Yeast.J Biol Chem. 2009 May 29;284(22):14828-37.

[2]. B K Wong,et al. Selective Effects of N-acetylcysteine Stereoisomers on Hepatic Glutathione and Plasma Sulfate in Mice. Toxicol Appl Pharmacol

[3]. Suparna Qanungo, et al. N-Acetyl-L-cysteine Enhances Apoptosis Through Inhibition of Nuclear factor-kappaB in Hypoxic Murine Embryonic Fibroblasts. J Biol Chem

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
407.7±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₅H₉NO₃S

[ Molecular Weight ]:
163.195

[ Flash Point ]:
200.4±27.3 °C

[ Exact Mass ]:
163.030319

[ PSA ]:
108.69000

[ LogP ]:
-0.15

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.519

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.