gentamycin C1a

Names

[ Name ]:
gentamycin C1a

[Synonym ]:
Geneticin C1a
Gentamicin C1a Pentaacetate Salt
GentaMycin C1a Acetate
Gentamycin C1a
GentaMicin C3 Acetate
Gentamisin C3
Gentamicin D
Gentamicin C1a
GentaMicin D Acetate
Gentamicin C3

Biological Activity

[Description]:

Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Gentamicin C1a 抑制 Escherichia coli,P. aeruginosa 和 S. aureus 活性，IC50 值为 1 mg/mL[2]。 Gentamicin C1a (2 mM, 48 h) 对 OC-k3 细胞活力没有影响[2].

[In Vivo]

Gentamicin C1a (4 mg/kg，静脉推注剂量，单次) 在比格犬体内的平均停留时间为 84 分钟，CL 值为 1.81 mL/min/kg[3]。

[References]

[1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7.

[2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410.

[3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7.

Chemical & Physical Properties

[ Density]:
1.36g/cm3

[ Boiling Point ]:
675.2ºC at 760 mmHg

[ Melting Point ]:
102-108ºC

[ Molecular Formula ]:
C₁₉H₃₉N₅O₇

[ Molecular Weight ]:
449.54200

[ Flash Point ]:
362.1ºC

[ Exact Mass ]:
449.28500

[ PSA ]:
213.72000

[ Vapour Pressure ]:
3.97E-21mmHg at 25°C

[ Index of Refraction ]:
1.603

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2290000

CHEMICAL NAME :: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy ranosyl-(1-6)-O-(2,6- diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyrano syl-(1-4))-2-deoxy-

CAS REGISTRY NUMBER :: 26098-04-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H39-N5-O7

MOLECULAR WEIGHT :: 449.63

WISWESSER LINE NOTATION :: T6OTJ CQ DM1 EQ E1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CZ F1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977

Safety Information

[ Hazard Codes ]:
Xn

[ HS Code ]:
3004909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 3004909090

Related Compounds

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