Avenaciolide

Names

[ Name ]:
Avenaciolide

[Synonym ]:
dl-Avenaciolid
dl-avenaciolide
(3aR,4R,6aR)-3-Methylene-4-octyl-dihydro-furo[3,4-b]furan-2,6-dione
(+-)-Avenaciolid

Biological Activity

[Description]:

Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Castelo-Branco PA, et al. Synthesis and antifungal activity of aromatic bis-gamma-lactones analogous to avenaciolide. Chem Biodivers. 2007;4(12):2745-2754.

[2]. McGivan JD, Chappell JB. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. Biochem J. 1970;116(4):37P-38P.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₂₂O₄

[ Molecular Weight ]:
266.33300

[ Exact Mass ]:
266.15200

[ PSA ]:
52.60000

[ LogP ]:
2.76020

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.