FP-Biotin

Names

[ Name ]:
FP-Biotin

[Synonym ]:
FP-biotin

Biological Activity

[Description]:

FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

FP-biotin has good reactivity with human AChE and BChE despite its large biotin group. FP-biotin is suitable for the proposed task of identifying organophosphorus toxicants reactive proteins[1].

[References]

[1]. Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18(4):747-754.

[2]. Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12(3):852-861.

[3]. Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180(3):492-498.

Chemical & Physical Properties

[ Density]:
1.125g/cm3

[ Boiling Point ]:
851.3ºC at 760 mmHg

[ Molecular Formula ]:
C₂₇H₅₀FN₄O₅PS

[ Molecular Weight ]:
592.75

[ Flash Point ]:
468.6ºC

[ Exact Mass ]:
592.32200

[ PSA ]:
171.21000

[ LogP ]:
7.08420

[ Vapour Pressure ]:
2.82E-29mmHg at 25°C

[ Index of Refraction ]:
1.497

Related Compounds

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