CGP78850

CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

Grb2 SH2-phosphopeptide[1]

CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1]. CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: MDA-MB-468 cells Concentration: 0~100 μM Incubation Time: 90 minutes Result: Reduced the amount of associated Grb2 protein in a dose-dependent manner.

[1]. Gay B, et al. Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer. 1999;83(2):235-241.