Antitumor agent-45

Names

[ Name ]:
Antitumor agent-45

Biological Activity

[Description]:

Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR

[In Vitro]

Antitumor agent-45 (Compound 21) enhibits IC50 values of 1.06, 10.87 and 0.11 μM in A549, Hela and MCF-7 cells, respectively[1].

[References]

[1]. Jianqing Zhang, et al. Synthesis, bioevaluation and molecular dynamics of pyrrolo-pyridine benzamide derivatives as potential antitumor agents in vitro and in vivo. Eur J Med Chem. 2022 Apr 5;233:114215.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₁₇BrFN₅O₃

[ Molecular Weight ]:
570.37

Related Compounds

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