2581082-74-6

2581082-74-6 structure

Name: Antitumor agent-45
Chemical Name: Antitumor agent-45
CAS Number: 2581082-74-6
Molecular Formula: C₂₈H₁₇BrFN₅O₃
Molecular Weight: 570.37
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-01 09:09:48
Modify Date: 2025-08-25 20:33:49
Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells[1].

Name	Antitumor agent-45

Description	Antitumor agent-45 (Compound 21) could induce and stimulate A549 cells apoptosis in G0/G1 and G2/M phase. Antitumor agent-45 (Compound 21) inhibits c-Met expression to regulate the growth of tumor cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
In Vitro	Antitumor agent-45 (Compound 21) enhibits IC50 values of 1.06, 10.87 and 0.11 μM in A549, Hela and MCF-7 cells, respectively[1].
References	[1]. Jianqing Zhang, et al. Synthesis, bioevaluation and molecular dynamics of pyrrolo-pyridine benzamide derivatives as potential antitumor agents in vitro and in vivo. Eur J Med Chem. 2022 Apr 5;233:114215.

Molecular Formula	C₂₈H₁₇BrFN₅O₃
Molecular Weight	570.37