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Iseganan

Names

[ CAS No. ]:
257277-05-7

[ Name ]:
Iseganan

[Synonym ]:
L-Leucinamide, L-arginylglycylglycyl-N-[(1R,4S,7R,12R,15S,18R,21S,24S,30S)-12-[(3S,9S)-14-amino-9-(aminocarbonyl)-14-imino-3-(1-methylethyl)-1,4,7-trioxo-2,5,8,13-tetraazatetradec-1-yl]-24,30-bis[3-[(aminoiminomethyl)amino]propyl]-4-[(4-hydroxyphenyl)methyl]-15-(1-methylethyl)-3,6,14,17,20,23,26,29,32-nonaoxo-21-(phenylmethyl)-9,10,34,35-tetrathia-2,5,13,16,19,22,25,28,31-nonaazabicyclo[16.14.4]hexatriacont-7-yl]-
L-Arginylglycylglycyl-N-[(1R,4S,7R,12R,15S,18R,21S,24S,30S)-12-({(2S)-1-[(2-{[(2S)-1-amino-5-carbamimidamido-1-oxo-2-pentanyl]amino}-2-oxoethyl)amino]-3-methyl-1-oxo-2-butanyl}carbamoyl)-21-benzyl-24,30-bis(3-carbamimidamidopropyl)-4-(4-hydroxybenzyl)-15-isopropyl-3,6,14,17,20,23,26,29,32-nonaoxo-9,10,34,35-tetrathia-2,5,13,16,19,22,25,28,31-nonaazabicyclo[16.14.4]hexatriacont-7-yl]-L-leucinamide
iseganan

Biological Activity

[Description]:

Iseganan is an antimicrobial peptide, shows broad-spectrum anti-bacteria and fungi activity. Iseganan can be used in oral mucositis research[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Iseganan (200 and 400 μg/mL; 24 h) disrupts T. crassiceps cysticerci in vitro[3]. Cell Viability Assay[3] Cell Line: Cysticerci Concentration: 200 and 400 μg/mL Incubation Time: 24 hours Result: Showed loss of motility, size decreasement, as well as disruption of the bladder wall.

[In Vivo]

Iseganan (intraperitoneal injection; 200 and 400 μg per mouse; once) shows anti-parasite activity in T. crassiceps murine cysticercosis model[3]. Animal Model: Female BALB/cAnN mice injected with T. crassiceps[3] Dosage: 200 and 400 μg per mouse Administration: Intraperitoneal injection; 200 and 400 μg per mouse; once Result: Reduced the parasite load by 25% when compared with the control group.

[References]

[1]. Toney JH. Iseganan (IntraBiotics pharmaceuticals). Curr Opin Investig Drugs. 2002 Feb;3(2):225-8.

[2]. Giles FJ, et al. Iseganan HCl: a novel antimicrobial agent. Expert Opin Investig Drugs. 2002 Aug;11(8):1161-70.

[3]. Landa A, et al. Antimicrobial peptides (Temporin A and Iseganan IB-367): effect on the cysticerci of Taenia crassiceps. Mol Biochem Parasitol. 2009 Apr;164(2):126-30.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C78H126N30O18S4

[ Molecular Weight ]:
1900.285

[ Exact Mass ]:
1898.874878

[ LogP ]:
-4.99

[ Index of Refraction ]:
1.705

Related Compounds

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