N-Methyl-DL-valine

Names

[ Name ]:
N-Methyl-DL-valine

[Synonym ]:
methyl-valine
N-Methylvaline hydrochloride
N-METHYL-DL-VALINE HYDROCHLORIDE
Valine, N-methyl-, hydrochloride (1:1)
H-(S,R)-NMeVal-OH
N-ME-DL-VAL-OH HCL
N-Methyl-dl-valine,HCl
N-methyl-valine
N-Methylvaline hydrochloride (1:1)

Biological Activity

[Description]:

N-Methyl-DL-valine is a valine derivant, is metabolized to cysteine, alanine, tyrosine, tryptophan, citric acid, and succinic acid in the sprout. N-Methyl-DL-valine involves in the modification of monomethyl auristatin F (MMAF), an anti-tubulin agent, makes it hydrophobic functionalization and increases cell permeability[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. M. Pasteels, et al. Uptake and metabolism of [14C]rinderine and [14C]retronecine in leaf-beetles of the genus Platyphora and alkaloid accumulation in the exocrine defensive secretions. Chemoecology. 2003;13:55–62.

[2]. Philip N Moquist, et al. Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux–positive Tumor Models. Mol Cancer Ther.2021;20(2): 320–328.

Chemical & Physical Properties

[ Density]:
0.995

[ Melting Point ]:
82-84ºC

[ Molecular Formula ]:
C₆H₁₄ClNO₂

[ Molecular Weight ]:
167.634

[ Exact Mass ]:
167.071304

[ PSA ]:
49.33000

[ LogP ]:
1.50790

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Investigation of 60Co γ-irradiated l-(−) malic acid, N-methyl-dl-valine and l-glutamic acid γ-ethyl ester by electron paramagnetic resonance technique Baskin, M.H., Aydin, M., and Osmanoğlu, S.

J. Mol. Struct. 983 , 200-202, (2010)