3’-O-MOE-G(iBu)-2’-phosphoramidite

Names

[ Name ]:
3’-O-MOE-G(iBu)-2’-phosphoramidite

Biological Activity

[Description]:

3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₇H₆₀N₇O₁₀P

[ Molecular Weight ]:
913.99

Related Compounds

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