ABCG2-IN-2

Names

[ CAS No. ]:
2559759-59-8

[ Name ]:
ABCG2-IN-2

Biological Activity

[Description]:

ABCG2-IN-2 is a potent ABCG2 inhibitor with favorable oral pharmacokinetic profiles in mice. ABCG2-IN-2 can be used for the research of tumor multidrug resistance (MDR) and erythropoietic protoporphyria (EPP)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP

[References]

[1]. Zhu J, et al. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. Eur J Med Chem. 2023 Nov 5;259:115666. doi: 10.1016/j.ejmech.2023.115666. Epub 2023 Jul 20.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H34N4O4

[ Molecular Weight ]:
454.56