Bis-PEG3-sulfonic acid

Names

[ Name ]:
Bis-PEG3-sulfonic acid

[Synonym ]:
Ethanesulfonic acid, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
MFCD29042373
2,2'-[Oxybis(2,1-ethanediyloxy)]diethanesulfonic acid

Biological Activity

[Description]:

Bis-PEG3-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₈H₁₈O₉S₂

[ Molecular Weight ]:
322.353

[ Exact Mass ]:
322.039215

[ LogP ]:
-4.40

[ Index of Refraction ]:
1.512

Related Compounds

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