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3'-Chloro-3'-deoxythymidine

Names

[ CAS No. ]:
25526-94-7

[ Name ]:
3'-Chloro-3'-deoxythymidine

[Synonym ]:
3'-Chloro-3'-deoxythymidine (Zidovudine Related Compound B)
Zidovudine Related Compound B
3'-Chloro-3'-deoxythymidine
Thymidine, 3'-chloro-3'-deoxy-

Biological Activity

[Description]:

3′-Chloro-3′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C10H13ClN2O4

[ Molecular Weight ]:
260.67

[ Exact Mass ]:
260.056396

[ PSA ]:
84.32000

[ LogP ]:
-0.63

[ Index of Refraction ]:
1.598

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds