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Kushenol X

Names

[ CAS No. ]:
254886-77-6

[ Name ]:
Kushenol X

[Synonym ]:
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-8-[5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2R,3R)-
(2R,3R)-2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-[(2R)-2-isopropenyl-5-methyl-4-hexen-1-yl]-2,3-dihydro-4H-chromen-4-one
Kushenol X
(2R,3R)-2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-8-(2-isopropenyl-5-methyl-4-hexen-1-yl)-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-3,5,7-trihydroxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2R,3R)-

Biological Activity

[Description]:

Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and human carboxylesterase 2 (hCE2) inhibitor with IC50s of 2.07 μM and 3.05 μM, respectively[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: 2.07 μM (β-glucuronidase)[1] and 3.05 μM (Human carboxylesterase 2 (hCE2))[2]


[References]

[1]. Cheng-Peng Sun, et al. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase. Int J Biol Macromol. 2020 Jan 15;143:349-358.

[2]. Sha-Sha Song, et al. Flavonoids as human carboxylesterase 2 inhibitors: Inhibition potentials and molecular docking simulations. Int J Biol Macromol. 2019 Jun 15;131:201-208.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
699.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H28O7

[ Molecular Weight ]:
440.486

[ Flash Point ]:
238.8±25.0 °C

[ Exact Mass ]:
440.183502

[ PSA ]:
127.45000

[ LogP ]:
5.74

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.640

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds