(+)-Afzelechin

Names

[ Name ]:
(+)-Afzelechin

[Synonym ]:
(2R,3R)-2-(4-Hydroxyphenyl)-3,5,7-chromanetriol
(-)-epiafzelechin
2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(4-hydroxyphenyl)-, (2R,3R)-
Afzelechin
2H-1-Benzopyran-3,5,7-triol, 3,4-dihydro-2-(4-hydroxyphenyl)-, (2R,3S)-
(2R,3R)-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
epi-Afzelechin
3,5,7,4'-Tetrahydroxyflavan
(2R,3S)-2-(4-Hydroxyphenyl)-3,5,7-chromanetriol
2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

Biological Activity

[Description]:

(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an alpha-glucosidase activity inhibitor with an ID50 (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[Target]

ID50: 0.13 mM (alpha-glucosidase)[1]

[References]

[1]. Junichi Saijyo, et al. Alpha-glucosidase Inhibitor From Bergenia Ligulata. J Oleo Sci. 2008;57(8):431-5.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
583.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₄O₅

[ Molecular Weight ]:
274.269

[ Flash Point ]:
306.6±30.1 °C

[ Exact Mass ]:
274.084137

[ PSA ]:
90.15000

[ LogP ]:
1.09

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.709

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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