KNa1.1 inhibitor 31

Names

[ Name ]:
KNa1.1 inhibitor 31

Biological Activity

[Description]:

KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF.

[References]

1. Andrew M Griffin, et al. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₂F₆N₆O₂

[ Molecular Weight ]:
434.302

Related Compounds

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