KNa1.1 inhibitor 31
Names
[ CAS No. ]:
2540502-26-7
[ Name ]:
KNa1.1 inhibitor 31
Biological Activity
[Description]:
KNa1.1 inhibitor 31 is a potent, selective, orally available inhibitor of sodium-activated potassium channel KNa1.1 (Slack, Slo2.2) with IC50 of 40 nM (hKNa1.1 WT).KNa1.1 inhibitor 31 reduced seizures and interictal spikes in a mouse model of KCNT1 GoF.
[References]
1. Andrew M Griffin, et al. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602.
Chemical & Physical Properties
[ Molecular Formula ]:
C16H12F6N6O2
[ Molecular Weight ]:
434.302