JKA3 inhibitor 31

Names

[ Name ]:
JKA3 inhibitor 31

Biological Activity

[Description]:

JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases; also inhibits BLK, ERB-B4 and ITK with IC50 of 22 nM, 44 nM and 221 nM, respectively.

[References]

References 1. London N, et al. Nat Chem Biol. 2014 Dec;10(12):1066-72. 2. Clark JD, et al. J Med Chem. 2014 Jun 26;57(12):5023-38. View Related Products by Target JAK

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₂N₄O

[ Molecular Weight ]:
288.31

Related Compounds

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