Kurzipene D

Names

[ CAS No. ]:
2522596-01-4

[ Name ]:
Kurzipene D

Biological Activity

[Description]:

Kurzipene D (compound 4) is a potent anticancer agent. Kurzipene D induces the apoptosis and arrested the HepG2 cell cycle at S stage. Kurzipene D shows anti-tumor effects using in vivo zebrafish model. Kurzipene D has the property of inhibiting tumor proliferation and migration[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Kurzipene D (compound 4) shows strong cytotoxic activity against cancer cells K562, HepG2, A549, and HeLa, with IC50 values of 7.2 ± 0.4, 9.7 ± 0.3, 10.9 ± 0.6, and 12.4 ± 1.0, respectively[1].

[References]

[1]. Liang Y, et al. Diterpenoids from the leaves of Casearia kurzii showing cytotoxic activities. Bioorg Chem. 2020 May;98:103741.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H36O8

[ Molecular Weight ]:
476.56

Related Compounds