(R)-(-)-NIPECOTIC ACID ETHYL ESTER

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
238.6±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₅NO₂

[ Molecular Weight ]:
157.210

[ Flash Point ]:
90.6±0.0 °C

[ Exact Mass ]:
157.110275

[ PSA ]:
38.33000

[ LogP ]:
0.96

[ Vapour Pressure ]:
0.0±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.449

[ Storage condition ]:
Refrigerator

Click to get detail MSDS

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38-41-37/38

[ Safety Phrases ]:
S26-S36/37/39-S39-S36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933399090

Click to get detail synthetic route

Precursor

DownStream

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

THIP analgesia: cross tolerance with morphine.

Life Sci. 32(19) , 2265-72, (1983)

THIP (4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridone-3-ol), a direct acting GABA receptor agonist, has been shown to have antinociceptive properties. To determine whether tolerance develops to the analg...

(R)-nipecotic acid ethyl ester: a direct-acting cholinergic agonist that displays greater efficacy at M2 than at M1 muscarinic receptors.

J. Pharmacol. Exp. Ther. 242(1) , 173-8, (1987)

Previous reports have suggested that the ethyl ester of (R)-nipecotic acid ethyl ester [(R)-NAEE] displays cholinomimetic properties in vivo. The present study was undertaken to characterize more full...

Differential effects of ethyl (R,S)-nipecotate on the behaviors of highly and minimally aggressive female golden hamsters.

Psychopharmacology 89(4) , 444-8, (1986)

The GABA uptake inhibitor ethyl (R,S)-nipecotate produces a dose-dependent suppression of aggression in highly aggressive hamsters but not in minimally aggressive ones. This suppression occurs at dose...

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